NOT KNOWN FACTUAL STATEMENTS ABOUT KETAMINE FOR CRPS

Metabolism Ketamine is metabolized by using N-dealkylation on the active metabolite norketamine mainly by CYP2B6 and CYP3A4 and also to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation on the cyclohexone ring to sort hydroxynorketamine compounds by using CYP-dependent pathways, which are conjugated with glucuronic acid and